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Blepharospasm and orofacial‐cervical dystonia: Clinical and pharmacological findings in 100 patients

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Blepharospasm and orofacial‐cervical dystonia: Clinical and pharmacological findings in 100 patients

Auteurs : Joseph Jankovic [États-Unis] ; Janet Ford

Source :

Annals of Neurology [ 0364-5134 ] ; 1983-04.

RBID : ISTEX:AB71A428870EC10BBB903DD6F09299B8AD90819A

Descripteurs français

Wicri :
- topic : Neurologie.

English descriptors

Abstract

We evaluated prospectively 100 patients, the largest reported series, with blepharospasm and orofacial‐cervical dystonia, or Meige syndrome. The mean age at onset was 51.7 years, and 81% presented between the ages of 40 and 70. Women outnumbered men three to two. Blepharospasm was the initial symptom in 58 patients, but only 23 had involuntary movements localized to the orbicularis oculi. Sixty‐one patients had the complete syndrome, blepharospasm and oromandibular dystonia, and 60 had neck or generalized dystonia in addition to the orofacial movements. Twenty‐one patients with spasmodic dysphonia were included; in 12 of these patients, spasmodic dysphonia was part of the complete (Meige) syndrome, and 16 of these patients had neck or generalized dystonia or essential tremor. An organic cause of Meige syndrome is supported by a high correlation with essential tremor and other movement disorders and by positive family history in some patients. Response to medication was inconsistent, but 69% of patient trials resulted in some improvement; in 22% the benefit was marked and persistent. Tetrabenazine, lithium, and trihexyphenidyl were most useful for the treatment of oromandibular dystonia, and clonazepam was useful in some patients with blepharospasm.

Url:

https://api.istex.fr/document/AB71A428870EC10BBB903DD6F09299B8AD90819A/fulltext/pdf

DOI: 10.1002/ana.410130406

Affiliations:

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Le document en format XML

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<term>Additional patients</term>
<term>Arch neurol</term>
<term>Basal ganglia</term>
<term>Blepharospasm</term>
<term>Brainstem</term>
<term>Clonazepam</term>
<term>Dopamine</term>
<term>Dopaminergic</term>
<term>Dyskinesia</term>
<term>Dysphonia</term>
<term>Dystonia</term>
<term>Dystonic</term>
<term>Dystonic spasms</term>
<term>Essential blepharospasm</term>
<term>Essential tremor</term>
<term>Facial</term>
<term>Facial dystonia</term>
<term>Facial movements</term>
<term>Facial muscles</term>
<term>Family history</term>
<term>Female preponderance</term>
<term>Generalized dystonia</term>
<term>Head tremor</term>
<term>High incidence</term>
<term>Huntington disease</term>
<term>Hypothyroidism</term>
<term>Involuntary movements</term>
<term>Jankovic</term>
<term>Lithium</term>
<term>Many patients</term>
<term>Meige</term>
<term>Meige disease</term>
<term>Meige syndrome</term>
<term>Multiple sclerosis</term>
<term>Neurol</term>
<term>Neuroleptic</term>
<term>Neurology</term>
<term>Orbicularis oculi</term>
<term>Oromandibular</term>
<term>Oromandibular dystonia</term>
<term>Palatal myoclonus</term>
<term>Parkinson disease</term>
<term>Patient trials</term>
<term>Rostral brainstem</term>
<term>Spasmodic</term>
<term>Spasmodic dysphonia</term>
<term>Spontaneous dyskinesia</term>
<term>Syndrome</term>
<term>Tardive</term>
<term>Tardive dyskinesia</term>
<term>Tardive dystonia</term>
<term>Tetrabenazine</term>
<term>Torsion dystonia</term>
<term>Transient improvement</term>
<term>Tremor</term>
<term>Trihexyphenidyl</term>
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<front><div type="abstract" xml:lang="en">We evaluated prospectively 100 patients, the largest reported series, with blepharospasm and orofacial‐cervical dystonia, or Meige syndrome. The mean age at onset was 51.7 years, and 81% presented between the ages of 40 and 70. Women outnumbered men three to two. Blepharospasm was the initial symptom in 58 patients, but only 23 had involuntary movements localized to the orbicularis oculi. Sixty‐one patients had the complete syndrome, blepharospasm and oromandibular dystonia, and 60 had neck or generalized dystonia in addition to the orofacial movements. Twenty‐one patients with spasmodic dysphonia were included; in 12 of these patients, spasmodic dysphonia was part of the complete (Meige) syndrome, and 16 of these patients had neck or generalized dystonia or essential tremor. An organic cause of Meige syndrome is supported by a high correlation with essential tremor and other movement disorders and by positive family history in some patients. Response to medication was inconsistent, but 69% of patient trials resulted in some improvement; in 22% the benefit was marked and persistent. Tetrabenazine, lithium, and trihexyphenidyl were most useful for the treatment of oromandibular dystonia, and clonazepam was useful in some patients with blepharospasm.</div>
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Blepharospasm and orofacial‐cervical dystonia: Clinical and pharmacological findings in 100 patients

Blepharospasm and orofacial‐cervical dystonia: Clinical and pharmacological findings in 100 patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri